Methods and systems for prioritizing user symptom complaint inputs

ABSTRACT

A system for prioritizing user symptom complaint inputs. The system includes a KNN module operating on at least a computing device configured to receive a plurality of symptom complaint datums, receive suspected disease state training data, calculate an optimal vector output utilizing a k-nearest neighbor algorithm and generate an optimal vector output containing a suspected disease state. The system includes a triage module operating on at least a computing device configured to receive the optimal vector output, generate a triage urgency category label, select triage training data as a function of the triage urgency label, generate using a supervised machine-learning model a disease criticality model, evaluate the disease criticality score, and display the ranked disease criticality score for each of the plurality of suspected disease states.

FIELD OF THE INVENTION

The present invention generally relates to the field of artificialintelligence. In particular, the present invention is directed tomethods and systems for prioritizing user symptom complaint inputs.

BACKGROUND

Accurate recommendations for prioritizing medical attention andtreatment of user complaints is fraught with inaccuracies. Knowing whatto treat first and when to seek treatment can be confusing. Inaccurateprioritization can lead to devastating results often causing complaintsto go untreated and frustrating patients and medical professionalsalike.

SUMMARY OF THE DISCLOSURE

In an aspect, A system for prioritizing user symptom complaint inputs.The system includes at least a computing device, wherein the at least acomputing device further comprises one or more network interfaces; anon-volatile memory; and including one or more processors. The systemincludes a KNN module operating on the at least a computing device theKNN module designed and configured to receive a plurality of symptomcomplaint datums generated by a user at a graphical user interfaceoperating on the at least a computing device; receive suspected diseasestate training data correlating at least an element of symptom complaintdata to suspected disease states from an expert knowledge databaselocated on the at least a computing device; calculate an optimal vectoroutput for each of the plurality of symptom complaint datums utilizing ak-nearest neighbor algorithm and the suspected disease state trainingdata; and generate an optimal vector output containing a suspecteddisease state for each of the plurality of symptom complaint datums. Thesystem includes a triage module operating on the at least a computingdevice the triage module designed and configured to receive the optimalvector output containing a suspected disease state for each of theplurality of symptom complaint datums; generate a triage urgencycategory label for each of the plurality of suspected disease stateswherein the triage urgency category label further comprises matching theoptimal vector output containing a suspected disease state for each ofthe plurality of symptom complaint datums to a triage urgency categorylabel; select triage training data as a function of the triage urgencycategory label for each of the plurality of suspected disease stateswherein the triage training data correlates suspected disease states torelative disease criticality scores; generate using a supervisedmachine-learning model a disease criticality model that outputs adisease criticality score for each of the plurality of suspected diseasestates utilizing the selected triage training data; evaluate the diseasecriticality score for each of the plurality of suspected disease statesas a function of ranking the disease criticality score for each of theplurality of suspected disease states; and display the ranked diseasecriticality score for each of the plurality of suspected disease statesat the graphical user interface operating on the at least a computingdevice.

In an aspect, a method of prioritizing user symptom complaint inputs thesystem comprising receiving by at least a computing device a pluralityof symptom complaint datums generated by a user at a graphical userinterface operating on the at least a computing device; receiving by theat least a computing device a suspected disease state training datacorrelating at least an element of symptom complaint data to suspecteddisease states from an expert knowledge database located on the at leasta computing device; calculating by the at least a computing device anoptimal vector output for each of the plurality of symptom complaintdatums utilizing a k-nearest neighbor algorithm and the suspecteddisease state training data; generating by the at least a computingdevice an optimal vector output containing a suspected disease state foreach of the plurality of symptom complaint datums; generating by the atleast a computing device a triage urgency category label for each of theplurality of suspected disease states wherein the triage urgencycategory label further comprises matching the optimal vector outputcontaining a suspected disease state for each of the plurality ofsymptom complaint datums to a triage urgency category label; selectingby the at least a computing device a triage training data as a functionof the triage urgency category label for each of the plurality ofsuspected disease states wherein the triage training data correlatessuspected disease states to relative disease criticality scores;generating by the at least a computing device using a supervisedmachine-learning model a disease criticality model that outputs adisease criticality score for each of the plurality of suspected diseasestates utilizing the selected triage training data; evaluating by the atleast a computing device the disease criticality score for each of theplurality of suspected disease states as a function of ranking thedisease criticality score for each of the plurality of suspected diseasestates; and displaying by the at least a computing device the rankeddisease criticality score for each of the plurality of suspected diseasestates at the graphical user interface operating on the at least acomputing device.

These and other aspects and features of non-limiting embodiments of thepresent invention will become apparent to those skilled in the art uponreview of the following description of specific non-limiting embodimentsof the invention in conjunction with the accompanying drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

For the purpose of illustrating the invention, the drawings show aspectsof one or more embodiments of the invention. However, it should beunderstood that the present invention is not limited to the precisearrangements and instrumentalities shown in the drawings, wherein:

FIG. 1 is a block diagram illustrating an exemplary embodiment of asystem for prioritizing user symptom complaint inputs;

FIG. 2 is a block diagram illustrating an exemplary embodiment of a KNNmodule;

FIG. 3 is a block diagram illustrating an exemplary embodiment of anexpert knowledge database;

FIG. 4 is a diagrammatic representation of a K-nearest neighboralgorithm;

FIG. 5 is a block diagram illustrating an exemplary embodiment of a userdatabase;

FIG. 6 is a block diagram illustrating an exemplary embodiment of atriage module;

FIG. 7 is a flow diagram illustrating an exemplary flow of triageurgency category label selection;

FIG. 8 is a block diagram illustrating an exemplary embodiment of atriage urgency database;

FIG. 9 is a process flow diagram illustrating an exemplary embodiment ofa method of prioritizing user symptom complaint inputs; and

FIG. 10 is a block diagram of a computing system that can be used toimplement any one or more of the methodologies disclosed herein and anyone or more portions thereof.

The drawings are not necessarily to scale and may be illustrated byphantom lines, diagrammatic representations and fragmentary views. Incertain instances, details that are not necessary for an understandingof the embodiments or that render other details difficult to perceivemay have been omitted.

DETAILED DESCRIPTION

At a high level, aspects of the present disclosure are directed tosystems and methods for prioritizing user symptom complaint inputs. Inan embodiment, at least a computing device receives a plurality ofsymptom complaint datums generated by a user at a graphical userinterface. Plurality of symptom complaint datums may includedescriptions of body symptoms that a user may be experiencing such asfor example fatigue, left shoulder pain, weakness, and insomnia. Atleast a computing device receives suspected disease state training datacorrelating at least an element of symptom complaint data to suspecteddisease states from an expert knowledge database. At least a computingdevice calculates an optimal vector output for each of the plurality ofsymptom complaint datums using a k-nearest neighbor algorithm and thesuspected disease state training data. At least a computing devicegenerates a triage urgency category label for each of the plurality ofsuspected disease states. Triage urgency category label may contain anindication as to how soon medical attention may be needed. At least acomputing device selects triage training data as a function of thetriage urgency category label for each of the plurality of suspecteddisease states wherein the triage training data correlates suspecteddisease states to relative disease criticality scores. At least acomputing device generates utilizing a supervised machine-learning modela disease criticality model that outputs a disease criticality score foreach of the plurality of suspected disease states utilizing the selectedtriage training data. At least a computing device evaluates the diseasecriticality score for each of the plurality of suspected disease statesas a function of ranking the disease criticality score. At least acomputing device displays the ranked disease criticality score for eachof the plurality of suspected disease states at the graphical userinterface operating on at least a computing device.

Referring now to FIG. 1, an exemplary embodiment of a system 100 forprioritizing user symptom complaints is illustrated. System 100 includesat least a computing device 104, wherein the at least a computing device104 further comprises one or more network interfaces, a non-volatilememory, and including one or more processors. Computing device 104, asused herein, includes any computing device 104 as described in thisdisclosure, including without limitation a microcontroller,microprocessor, digital signal processor (DSP) and/or system on a chip(SoC) as described in this disclosure. Computing device 104 may include,be included in, and/or communicate with a mobile device such as a mobiletelephone or smartphone. Computing device 104 may include at least aserver. At least a server may include a single computing device 104operating independently, or may include two or more computing device 104operating in concert, in parallel, sequentially or the like; two or morecomputing device 104 may be included together in a single computingdevice 104 or in two or more computing device 104. At least a server mayinteract with one or more additional devices as described below infurther detail via a network interface device. Network interface devicemay be utilized for connecting at least a server to one or more of avariety of networks, and one or more devices. Examples of a networkinterface device include, but are not limited to, a network interfacecard (e.g., a mobile network interface card, a LAN card), a modem, andany combination thereof. Examples of a network include, but are notlimited to, a wide area network (e.g., the Internet, an enterprisenetwork), a local area network (e.g., a network associated with anoffice, a building, a campus or other relatively small geographicspace), a telephone network, a data network associated with atelephone/voice provider (e.g., a mobile communications provider dataand/or voice network), a direct connection between two computing device104, and any combinations thereof. A network may employ a wired and/or awireless mode of communication. In general, any network topology may beused. Information (e.g., data, software etc.) may be communicated toand/or from a computer and/or a computing device 104. At least a servermay include but is not limited to, for example, a computing device 104or cluster of computing device 104 in a first location and a secondcomputing device 104 or cluster of computing device 104 in a secondlocation. At least a server may include one or more computing device 104dedicated to data storage, security, distribution of traffic for loadbalancing, and the like. At least a server may distribute one or morecomputing tasks as described below across a plurality of computingdevice 104 of computing device 104, which may operate in parallel, inseries, redundantly, or in any other manner used for distribution oftasks or memory between computing device 104. At least a server may beimplemented using a “shared nothing” architecture in which data iscached at the worker, in an embodiment, this may enable scalability ofsystem 100 and/or computing device 104.

With continued reference to FIG. 1, at least a computing device 104 maybe designed and/or configured to perform any method, method step, orsequence of method steps in any embodiment described in this disclosure,in any order and with any degree of repetition. For instance, at least acomputing device 104 may be configured to perform a single step orsequence repeatedly until a desired or commanded outcome is achieved;repetition of a step or a sequence of steps may be performed iterativelyand/or recursively using outputs of previous repetitions as inputs tosubsequent repetitions, aggregating inputs and/or outputs of repetitionsto produce an aggregate result, reduction or decrement of one or morevariables such as global variables, and/or division of a largerprocessing task into a set of iteratively addressed smaller processingtasks. At least a computing device 104 may perform any step or sequenceof steps as described in this disclosure in parallel, such assimultaneously and/or substantially simultaneously performing a step twoor more times using two or more parallel threads, processor cores, orthe like; division of tasks between parallel threads and/or processesmay be performed according to any protocol suitable for division oftasks between iterations. Persons skilled in the art, upon reviewing theentirety of this disclosure, will be aware of various ways in whichsteps, sequences of steps, processing tasks, and/or data may besubdivided, shared, or otherwise dealt with using iteration, recursion,and/or parallel processing.

With continued reference to FIG. 1, system 100 includes a k-nearestneighbors (KNN) module 108 operating on at least a computing device 104.KNN module 108 may include any hardware and/or software module. KNNmodule 108 is configured to receive a plurality of symptom complaintdatums 112 generated by a user at a graphical user interface operatingon at least a computing device 104. A “symptom complaint datum” as usedin this disclosure, includes a description of any body symptom and/ormedical condition that a user may be experiencing. A “body symptom” asused in this disclosure, includes any physical or mental feature whichis regarded as indicating a condition and/or disease. Physical and/ormental feature may include any sign and/or symptom relevant to apotential medical condition and/or symptom. Physical and/or mentalfeature may include a sign such as clubbing on fingernails or a symptomsuch as mental fatigue. Body symptom may include dizziness, fever,tiredness, sleepiness, nausea, shortness of breath, abdominal pain,hearing loss, inability to pass urine, profusive sweating, alopecia, andthe like. Body symptom may be located to one particular location of thebody such as a body symptom that includes a description of pelvis painor blurry vision in a user's left eye. Body symptom may be limited toone or more body systems such as a cardiovascular arrhythmia orabdominal bloating and fecal incontinence. Body symptom may be apparentas indicating to a user a particular condition and/or disease such aswhen a patient experiences a body symptom such as blood loss from aflesh wound. Body symptom may not be apparent as indicating to a user aparticular condition and/or disease such as when a patient experiences abody symptom such as tiredness due to a thyroid condition which the userbelieves is simply due to being overly fatigued. Body symptom mayinclude a remitting symptom, such as when symptoms improve or resolvecompletely. For instance and without limitation, symptoms of a commoncold such as stuffy nose, headache, sneezing, and congested sinuses mayoccur for several days and then resolve with or without treatment. Bodysymptom may include a chronic symptom, such as when symptoms arelong-lasting and recurrent. For example, foot pain experienced as aresult of diabetic neuropathy may be long-lasting symptoms experiencedthroughout the duration of a user having diabetes. Body symptom mayinclude a relapsing symptom, which may include a symptom that occurredin the past at some other point in time, resolved, and then returned.For example, symptoms of depression may not occur for years at a timebut then may return without notice. Symptom complaint datum 112, mayinclude a description of a body symptom that a user may be currentlyexperiencing and/or recently experienced. For example, symptom complaintdatum 112 may include a description of a blood coming out of a nostrilor low back pain after sitting or a description of jaw pain that occursupon waking.

With continued reference to FIG. 1, KNN module 108 receives a pluralityof symptom complaint datums 112 generated by a user at a graphical userinterface 116 operating on at least a computing device 104. Graphicaluser interface 116 may include without limitation, a form or othergraphical element having data entry fields, wherein user may enter aplurality of symptom complaint datum 112. Graphical user interface 116may include data entry fields that allow for a user to enter free formtextual inputs describing a plurality of symptom complaint datum 112.Graphical user interface 116 may provide drop-down lists, where usersmay be able to select one or more entries to indicate one or moresymptom complaint datum 112.

With continued reference to FIG. 1, KNN module 108 is further configuredto receive a plurality of symptom complaint datum 112 generated by auser at a user interface 120 operating on at least a computing device104. User interface 120 may perform, without limitation, speech-to-textalgorithms that change oral inputs into text, which may allow for a userto enter oral spoken symptom complaint datum to textual symptomcomplaint datum. User interface 120 may utilize speech-to-textalgorithms that include automatic speech recognition, computer speechrecognition, and/or speech to text. User interface 120 may requiretraining of user interface 120 whereby an individual may read text orvocabulary into the user interface 120 to train the system. In anembodiment, user interface 120 may recognize the voice of the user asthey speak. User interface 120 may utilize models including HiddenMarkov models, dynamic time warping based speech recognition, neuralnetworks, deep feedforward and recurrent neural networks, and/orend-to-end automatic speech recognition.

With continued reference to FIG. 1, computing device 104 may includelanguage processing module 124. Language processing module 124 mayinclude any hardware and/or software module. Language processing module124 may be configured to extract, from the one or more documents, one ormore words. One or more words may include, without limitation, stringsof one or characters, including without limitation any sequence orsequences of letters, numbers, punctuation, diacritic marks, engineeringsymbols, geometric dimensioning and tolerancing (GD&T) symbols, chemicalsymbols and formulas, spaces, whitespace, and other symbols, includingany symbols usable as textual data as described above. Textual data maybe parsed into tokens, which may include a simple word (sequence ofletters separated by whitespace) or more generally a sequence ofcharacters as described previously. The term “token,” as used herein,refers to any smaller, individual groupings of text from a larger sourceof text; tokens may be broken up by word, pair of words, sentence, orother delimitation. These tokens may in turn be parsed in various ways.Textual data may be parsed into words or sequences of words, which maybe considered words as well. Textual data may be parsed into “n-grams”,where all sequences of n consecutive characters are considered. Any orall possible sequences of tokens or words may be stored as “chains”, forexample for use as a Markov chain or Hidden Markov Model.

Still referring to FIG. 1, language processing module 124 may operate toproduce a language processing model. Language processing model mayinclude a program automatically generated by at least a server and/orlanguage processing module 124 to produce associations between one ormore words extracted from at least a document and detect associations,including without limitation mathematical associations, between suchwords, and/or associations of extracted words. Associations betweenlanguage elements, where language elements include for purposes hereinextracted words, categories of physiological data, relationships of suchcategories to constitution symptom complaints may include, withoutlimitation, mathematical associations, including without limitationstatistical correlations between any language element and any otherlanguage element and/or language elements. Statistical correlationsand/or mathematical associations may include probabilistic formulas orrelationships indicating, for instance, a likelihood that a givenextracted word indicates a given category of body symptoms. As a furtherexample, statistical correlations and/or mathematical associations mayinclude probabilistic formulas or relationships indicating a positiveand/or negative association between at least an extracted word and/or agiven category of symptoms; positive or negative indication may includean indication that a given document is or is not indicating a particularbody symptom or is not significant. For instance, and withoutlimitation, a negative indication may be determined from a phrase suchas “head pain was not associated with neck pain,” whereas a positiveindication may be determined from a phrase such as “back pain wasassociated with decreased urine output,” as an illustrative example;whether a phrase, sentence, word, or other textual element in a documentor corpus of documents constitutes a positive or negative indicator maybe determined, in an embodiment, by mathematical associations betweendetected words, comparisons to phrases and/or words indicating positiveand/or negative indicators that are stored in memory on a computingdevice 104 or the like.

Still referring to FIG. 1, language processing module 124 and/or atleast a computing device 104 may generate the language processing modelby any suitable method, including without limitation a natural languageprocessing classification algorithm; language processing model mayinclude a natural language process classification model that enumeratesand/or derives statistical relationships between input term and outputterms. Algorithm to generate language processing model may include astochastic gradient descent algorithm, which may include a method thatiteratively optimizes an objective function, such as an objectivefunction representing a statistical estimation of relationships betweenterms, including relationships between input terms and output terms, inthe form of a sum of relationships to be estimated. In an alternative oradditional approach, sequential tokens may be modeled as chains, servingas the observations in a Hidden Markov Model (HMM). HMMs as used herein,are statistical models with inference algorithms that that may beapplied to the models. In such models, a hidden state to be estimatedmay include an association between an extracted word and a givenrelationship of an extracted word to a particular symptom. There may bea finite number of category of symptoms, and/or a given relationship ofsuch words to category of symptoms; an HMM inference algorithm, such asthe forward-backward algorithm or the Viterbi algorithm, may be used toestimate the most likely discrete state given a word or sequence ofwords. Language processing module 124 may combine two or moreapproaches. For instance, and without limitation, machine-learningprogram may use a combination of Naive-Bayes (NB), Stochastic GradientDescent (SGD), and parameter grid-searching classification techniques;the result may include a classification algorithm that returns rankedassociations.

Continuing to refer to FIG. 1, generating language processing model mayinclude generating a vector space, which may be a collection of vectors,defined as a set of mathematical objects that can be added togetherunder an operation of addition following properties of associativity,commutativity, existence of an identity element, and existence of aninverse element for each vector, and can be multiplied by scalar valuesunder an operation of scalar multiplication compatible with fieldmultiplication, and that has an identity element is distributive withrespect to vector addition, and is distributive with respect to fieldaddition. Each vector in an n-dimensional vector space may berepresented by an n-tuple of numerical values. Each unique extractedword and/or language element as described above may be represented by avector of the vector space. In an embodiment, each unique extractedand/or other language element may be represented by a dimension ofvector space; as a non-limiting example, each element of a vector mayinclude a number representing an enumeration of co-occurrences of theword and/or language element represented by the vector with another wordand/or language element. Vectors may be normalized, scaled according torelative frequencies of appearance and/or file sizes. In an embodimentassociating language elements to one another as described above mayinclude computing a degree of vector similarity between a vectorrepresenting each language element and a vector representing anotherlanguage element; vector similarity may be measured according to anynorm for proximity and/or similarity of two vectors, including withoutlimitation cosine similarity, which measures the similarity of twovectors by evaluating the cosine of the angle between the vectors, whichcan be computed using a dot product of the two vectors divided by thelengths of the two vectors. Degree of similarity may include any othergeometric measure of distance between vectors.

Still referring to FIG. 1, language processing module 124 may use acorpus of documents to generate associations between language elementsin a language processing module 124, and at least a server may then usesuch associations to analyze words extracted from one or more documentsand determine that the one or more documents indicate significance of asymptom. In an embodiment, at least a server may perform this analysisusing a selected set of significant documents, such as documentsidentified by one or more experts as representing good science, goodclinical analysis, or the like; experts may identify or enter suchdocuments via graphical user interface 116 as described \, or maycommunicate identities of significant documents according to any othersuitable method of electronic communication, or by providing suchidentity to other persons who may enter such identifications into atleast a server. Documents may be entered into at least a server by beinguploaded by an expert or other persons using, without limitation, filetransfer protocol (FTP) or other suitable methods for transmissionand/or upload of documents; alternatively or additionally, where adocument is identified by a citation, a uniform resource identifier(URI), uniform resource locator (URL) or other datum permittingunambiguous identification of the document, at least a server mayautomatically obtain the document using such an identifier, for instanceby submitting a request to a database or compendium of documents such asJSTOR as provided by Ithaka Harbors, Inc. of New York.

With continued reference to FIG. 1, KNN module 108 is configured toreceive suspected disease state training data 128 correlating at leastan element of symptom complaint data to suspected disease state vectorsfrom an expert knowledge database located on at least a computing device104. “Training data,” as used in this disclosure, is data containingcorrelation that a machine-learning process may use to modelrelationships between two or more categories of data elements. Forinstance, and without limitation, training data may include a pluralityof data entries, each entry representing a set of data elements thatwere recorded, received, and/or generated together; data elements may becorrelated by shared existence in a given data entry, by proximity in agiven data entry, or the like. Multiple data entries in training datamay evince one or more trends in correlations between categories of dataelements; for instance, and without limitation, a higher value of afirst data element belonging to a first category of data element maytend to correlate to a higher value of a second data element belongingto a second category of data element, indicating a possible proportionalor other mathematical relationship linking values belonging to the twocategories. Multiple categories of data elements may be related intraining data according to various correlations; correlations mayindicate causative and/or predictive links between categories of dataelements, which may be modeled as relationships such as mathematicalrelationships by machine-learning processes as described in furtherdetail below. Training data may be formatted and/or organized bycategories of data elements, for instance by associating data elementswith one or more descriptors corresponding to categories of dataelements. As a non-limiting example, training data may include dataentered in standardized forms by persons or processes, such that entryof a given data element in a given field in a form may be mapped to oneor more descriptors of categories. Elements in training data may belinked to descriptors of categories by tags, tokens, or other dataelements; for instance, and without limitation, training data may beprovided in fixed-length formats, formats linking positions of data tocategories such as comma-separated value (CSV) formats and/orself-describing formats such as extensible markup language (XML),enabling processes or devices to detect categories of data.

Alternatively or additionally, and still referring to FIG. 1, trainingdata may include one or more elements that are not categorized; that is,training data may not be formatted or contain descriptors for someelements of data. Machine-learning algorithms and/or other processes maysort training data according to one or more categorizations using, forinstance, natural language processing algorithms, tokenization,detection of correlated values in raw data and the like; categories maybe generated using correlation and/or other processing algorithms. As anon-limiting example, in a corpus of text, phrases making up a number“n” of compound words, such as nouns modified by other nouns, may beidentified according to a statistically significant prevalence ofn-grams containing such words in a particular order; such an n-gram maybe categorized as an element of language such as a “word” to be trackedsimilarly to single words, generating a new category as a result ofstatistical analysis. Similarly, in a data entry including some textualdata, a person's name may be identified by reference to a list,dictionary, or other compendium of terms, permitting ad-hoccategorization by machine-learning algorithms, and/or automatedassociation of data in the data entry with descriptors or into a givenformat. The ability to categorize data entries automatedly may enablethe same training data to be made applicable for two or more distinctmachine-learning algorithms as described in further detail below.Training data used by at least a server 104 may correlate any input dataas described in this disclosure to any output data as described in thisdisclosure.

With continued reference to FIG. 1, KNN module 108 receives trainingdata correlating at least an element of symptom complaint data tosuspected disease state vectors. “Correlation” in a training data setmay include any relation established therein linking one datum toanother, including inclusion together in a data element, row, column,cell, or the like, and/or by giving each a common indicator and/or labelindicative of their correlation in data used to create and/or compiletraining data. Correlation may include a relation established whereby atleast an element of symptom complaint data is correlated to suspecteddisease state 140 vector based on data entries obtained from the samesubject. Training set may include a plurality of entries, each entrycorrelating at least an element of symptom complaint data to suspecteddisease state vectors.

With continued reference to FIG. 1, suspected disease state 140 vectormay be a data structure that represents a quantitative measure of adegree of probability of a user receiving a diagnosis from a medicalprofessional for having a particular disease and/or condition. Medicalprofessional may include any licensed health professional who may beauthorized by a medical licensing board to diagnose disease and/orconditions including for example, a medical doctor, a doctor ofosteopathy, a nurse practitioner, a physician assistant, a doctor ofoptometry, a doctor of dental medicine, a doctor of dental surgery, anaturopathic doctor, a doctor of physical therapy, a nurse, a doctor ofchiropractic medicine, a doctor of oriental medicine, and the like. A“suspected disease state 140 vector” as defined in this disclosure, is nn-tuple of values, where n is at least two values. Each value of n-tupleof values may represent a measurement or other quantitative valueassociated with a given category of data, or attribute, examples ofwhich are provided in further detail below; a vector may be represented,without limitation, in n-dimensional space using an axis per category ofvalue represented in n-tuple of values, such that a vector has ageometric direction characterizing the relative quantities of attributesin the n-tuple as compared to each other. Two vectors may be consideredequivalent where their directions, and/or the relative quantities ofvalues within each vector as compared to each other, are the same; thus,as a non-limiting example, a vector represented as [5, 10, 15] may betreated as equivalent, for purposes of this disclosure, as a vectorrepresented as [1, 2, 3]. Vectors may be more similar where theirdirections are more similar, and more different where their directionsare more divergent; however, vector similarity may alternatively oradditionally be determined using averages of similarities between likeattributes, or any other measure of similarity suitable for any n-tupleof values, or aggregation of numerical similarity measures for thepurposes of loss functions as described in further detail below. Anyvectors as described herein may be scaled, such that each vectorrepresents each attribute along an equivalent scale of values. Eachvector may be “normalized,” or divided by a “length” attribute, such asa length attribute l as derived using a Pythagorean norm: l=√{squareroot over (Σ_(i=0) ^(n)a_(i) ²)}, where a is attribute number i of thevector. Scaling and/or normalization may function to make vectorcomparison independent of absolute quantities of attributes, whilepreserving any dependency on similarity of attributes; this may, forinstance be advantageous where each vector represents a weighing of userpriorities, and/or is to be compared to such a weighing of userpriorities.

With continued reference to FIG. 1, KNN module 108 receives suspecteddisease state training data 128 from an expert knowledge database 132located on at least a computing device 104. Expert knowledge database132 may include any data structure for ordered storage and retrieval ofdata, which may be implemented as a hardware or software module. Anexpert knowledge database 132 may be implemented, without limitation, asa relational database, a key-value retrieval datastore such as a NOSQLdatabase, or any other format or structure for use as a datastore that aperson skilled in the art would recognize as suitable upon review of theentirety of this disclosure. Expert submissions may be provided in anysuitable manner, including using on or more entries on a graphical userinterface 116, for instance according to embodiments as described infurther detail below.

With continued reference to FIG. 1, KNN module 108 is configured tocalculate an optimal vector output 136 for each of the plurality ofsymptom complaint datum 112 utilizing a k-nearest neighbor algorithm andsuspected disease state training data 128. “Optimal vector output 136”as used in this disclosure, includes a “first guess” by KNN module 108at the nearest vector in the feature space containing a suspecteddisease state 140. K-nearest neighbor algorithm may return a singlematching entry or a plurality of matching entries. When a plurality ofmatching entries are returned, KNN module 108 may derive optimal vectorfrom plurality of matching entries by aggregating matching entries;aggregation may be performed using any suitable method for aggregation,including component-wise addition followed by normalization,component-wise calculation of arithmetic means, or the like. “K-nearestneighbor algorithm” as used in this disclosure, includes a lazy-learningmethod that utilizes feature similarity to analyze how closelyout-of-sample-features resemble training data to locate possible optimalvector output 136, classify possible optimal vector output 136,calculate an optimal vector output 136, and generate an optimal vectoroutput 136. Calculating an optimal vector output 136 utilizing ak-nearest neighbor algorithm may include specifying a K-value, selectingk entries in a database which are closest to the known sample,determining the most common classifier of the entries in the database,and classifying the known sample. A lazy-learning process and/orprotocol, which may alternatively be referred to as a “lazy loading” or“call-when-needed” process and/or protocol, may be a process wherebymachine-learning is conducted upon receipt of an input to be convertedto an output, by combining the input and training set to derive thealgorithm to be used to produce the output on demand. For instance, aninitial set of simulations may be performed to cover an initialheuristic and/or “first guess” at an output and/or relationship. As anon-limiting example, an initial heuristic may include a ranking ofassociations between inputs and elements of training data. Heuristic mayinclude selecting some number of highest-ranking associations and/ortraining data elements. Lazy learning may implement any suitable lazylearning algorithm, including without limitation a K-nearest neighborsalgorithm, a lazy naïve Bayes algorithm, or the like; persons skilled inthe art, upon reviewing the entirety of this disclosure, will be awareof various lazy-learning algorithms that may be applied to generateoutputs as described in this disclosure, including without limitationlazy learning applications of machine-learning algorithms as describedin further detail below.

With continued reference to FIG. 1, KNN module 108 is configured tocalculate an optimal vector output 136 by identifying the presence of asymptom complaint datum 112 and confirming a suspected disease state.“Confirming a suspected disease state” as used in this disclosure,includes identifying a suspected disease state that may be included inoptimal vector output 136. Suspected disease state 140 may include adisease state and/or condition that may be subsequently diagnosed by amedical professional due to the presence or absence of symptomsexperienced by a user. Medical professional may include any of themedical professionals as described herein. Suspected disease state 140may include a probable current disease state and/or medical conditionand/or future probable disease state and/or medical condition. Forinstance and without limitation, presence of a symptom such as a restingtremor may confirm a possible suspected disease state 140 such asParkinson's disease. In yet another non-limiting example, presence of asymptom such as head pain may be utilized to confirm a possiblesuspected disease state 140 such as migraine. In an embodiment, presenceof a symptom may be utilized to confirm a plurality of suspected diseasestate 140. For instance and without limitation, a symptom such as kneepain may be utilized to confirm a plurality of suspected disease state140 that include osteoarthritis, Lyme disease, and jumper's knee. In yetanother non-limiting example, a symptom such as fatigue may be utilizedto confirm a plurality of suspected disease state 140 that includeanemia, chronic fatigue syndrome, hypothyroidism, and fibromyalgia.Identification of the presence of a symptom complaint datum 112 may beutilized to eliminate a suspected disease state 140. For instance andwithout limitation, presence of a symptom such as left toe pain may beutilized to eliminate a suspected disease state 140 such as myocardialinfarction. In yet another non-limiting example, presence of a symptomsuch as tinnitus may be utilized to eliminate a suspected disease state140 such as acid reflux disease. Identification of the presence of asymptom complaint datum 112 may be utilized to eliminate a plurality ofsuspected disease state 140. For instance and without limitation,presence of a symptom such as a productive wet cough may be utilized toeliminate a plurality of suspected disease state 140 such as anxiety,dementia, and urinary tract infection.

With continued reference to FIG. 1, absence of a symptom may be utilizedto confirm a possible suspected disease state 140. For instance andwithout limitation, absence of a symptom such as absence of fever may beutilized to confirm a possible suspected disease state 140 such asparvovirus. Absence of a symptom may be utilized to eliminate a possiblesuspected disease state 140. For instance and without limitation,absence of a symptom such as diarrhea may be utilized to eliminate apossible suspected disease state 140 such as ulcerative colitis. In yetanother non-limiting example, absence of a symptom such as sweaty palmsmay be utilized to eliminate a possible suspected disease state 140 suchas hyperhidrosis.

With continued reference to FIG. 1, KNN module 108 is configured togenerate an optimal vector output 136 containing a suspected diseasestate 140 for each of the plurality of symptom complaint datums 112.Optimal vector output 136 includes any of the optimal vector output 136as described herein. Suspected disease state 140 includes any of thesuspected disease state 140 as described herein.

With continued reference to FIG. 1, generating an optimal vector output136 includes displaying the optimal vector output 136 containing asuspected disease state 140 to a user, receiving a user entry containinga datum of user genetic history, and updating the optimal vector output136 containing a new suspected disease state 140 as a function of theuser entry. An optimal vector output 136 may be displayed to a user viacomputing device 104, such as for example by displaying optimal vectoroutput 136 on a graphical user interface 116 indicating a first guess ata suspected disease state 140. Graphical user interface 116 may includeany of the graphical user interfaces 116 as described above. In anembodiment, optimal vector output 136 may display a plurality ofsuspected disease state 140. User entry generated in response todisplaying an optimal vector output 136 contains a datum of user genetichistory. “User genetic history” as used in this disclosure, includes asample extracted from a user that includes any sequence of nucleic acididentified in a user, including without limitation deoxyribonucleic acid(DNA) and/or ribonucleic acid (RNA). DNA may include chromosomal DNA,including without limitation sequences encoding particular genes as wellas sequences of DNA disposed between or after gene sequences, includingwithout limitation telomeres. Telomeres, as used in this description arecaps (repetitive nucleotide sequences) at the end of linear chromosomesof a user. Telomeres are theorized to play a critical role infacilitating complete chromosome replication. Telomeres arecharacterized by noncoding tandem arrays of a “TTAGGG” DNA sequence thatare located at the terminal ends of all vertebrate chromosomes,including those of humans. A G-rich single stranded 3-prime overhang ispresent at the end of human telomeres; this overhang, which may beimportant for telomere function folds back on itself forming a largeloop structure called a telomere loop, or T-loop, that has a shapesimilar to that of a paper clip. A telomere may be stabilized by asix-protein complex, known as “shelterin,” which may include telomericrepeat binding factor 1 and 2 (TRF1 and TRF2), protection of telomeres 1(POT1), TRF1 and TRF2 interacting nuclear protein 2 (TIN2), the humanortholog of the yeast repressor/activator protein 1 (Rap1), and TPP1.Telomere lengths have been observed to reduce over a series of cellularmitotic divisions, such that telomere length and/or changes in telomerelength appear to correlate with processes of cellular aging andsenescence. It is therefore hypothesized that telomere length and/orchanges thereto may be useful to predict life expectancy of a person;however, precise predictions have hitherto eluded researchers. A geneticsample may include mRNA, tRNA, or any other RNA sequence or strand.

With continued reference to FIG. 1, user genetic history may be obtainedfrom a physically extracted sample. “Physically extracted sample” asused in this disclosure, includes any methodology, equipment, device,and/or instrument utilized to collect a genetic history from a user.Physically extracted sample may include for example a tissue sample, abuccal swab, a fluid sample, a biopsy, a blood sample, a hair sample, asample obtained from a microchip sensor placed under the skin, and thelike. Physically extracted sample may be further processed such as bypolymerase chain reaction “PCR” processes, centrifuge processes,sub-sequences, and the like.

With continued reference to FIG. 1, KNN module 108 may receive a userentry containing a datum of user genetic history from a user database144 operating on at least a computing device 104. User database 144 maybe implemented in any way suitable for implementation of expert databaseas described above. User database 144 may include a plurality of dataentries and/or records corresponding to user genetic history. Dataentries in user database 144 may include additional elements ofinformation such as user demographic information which may be reflectedin data entry cells and/or in linked tables such as tables related byone or more indices in a relational database. Persons skilled in theart, upon reviewing the entirety of this disclosure, will be aware ofvarious ways in which data entries in a user database 144 may beorganized.

With continued reference to FIG. 1, optimal vector output 136 may beupdated to contain a new suspected disease state 140 as a function ofuser entry. Optimal vector output 136 may be updated to select and/oreliminate suspected disease state 140 as a function of user entrycontaining a datum of user genetic history. For instance and withoutlimitation, a datum of user genetic history showing one copy ofinherited HbSS gene may be utilized to select a suspected disease state140 that includes sickle cell disease. In yet another non-limitingexample, a datum of user genetic history showing an A/G genotype matrixfor the MCMG gene that controls production of lactase may be utilized toselect a suspected disease state 140 that includes lactose intolerance.In yet another non-limiting example, a datum of user genetic historyshowing an A/A genotype matrix for the MCMG gene that controlsproduction of lactase may be utilized to eliminate a suspected diseasestate 140 that includes lactose intolerance. In yet another non-limitingexample, a datum of user genetic history showing Greek ancestry may beutilized to select a suspected disease state 140 that includesthalassemia. In yet another non-limiting example, a datum of usergenetic history showing ancestry that is not of sub-Saharan Africanancestry may be utilized to eliminate a suspected disease state 140 thatincludes sickle-cell anemia.

With continued reference to FIG. 1, system 100 includes a triage module148 operating on at least a computing device 104. Triage module 148includes any hardware and/or software module. Triage module 148 isconfigured to receive at optimal vector output 136 containing asuspected disease state 140 for each of the plurality of symptomcomplaint datum 112.

With continued reference to FIG. 1, triage module 148 is configured togenerate a triage urgency category label 152 for each of the pluralityof constitution complaint datums wherein the triage urgency categorylabel 152 further comprises matching an optimal vector output 136containing a suspected disease state 140 for each of the plurality ofsymptom complaint datum 112 to a triage urgency category label 152.“Triage urgency category label 152” as used in this disclosure, includesa datum describing how urgent a particular suspected disease state 140for each of the plurality of symptom complaint datum 112 warrantsmedical attention. “Medical attention” as used in this disclosure,includes treatment received from a medical professional. Treatment mayinclude actual face to face treatment with a medical professional and/orvirtual treatment such as through an electronic video chat, web-chat,and/or phone call with a medical professional. Medical professional mayinclude any of the medical professionals as described herein. Triageurgency category label 152 may include an immediate attention label whenmedical attention is needed within the next hour. Triage urgencycategory label 152 may include an attention in the near future labelwhen medical attention is needed within the next three hours. Triageurgency category label 152 may include an attention in the next daylabel when medical attention is needed within the next twenty fourhours. Triage urgency category label 152 may include an attention in thenext week label when medical attention is needed within one week. Triageurgency category label 152 may include a check-up appointment label whenmedical attention can be delayed until a subsequently scheduledappointment. Triage urgency category label 152 may include a self-carelabel when medical attention is not warranted, and a user can utilizehome treatment such as when utilizing over the counter andnon-prescription treatments.

With continued reference to FIG. 1, triage module 148 may match anoptimal vector output 136 containing a suspected disease state 140 to atriage urgency category label 152. Matching may include calculating atriage urgency algorithm that may be indicative in determining how soonmedical attention is needed. Triage urgency algorithm includesmultiplying a body system factor by a life endangerment factor and analarm condition factor. Triage urgency algorithm may output a numericalscore with each factor utilized to calculate triage urgency algorithmbeing given an individual score that is multiplied together. Higherfinal values for triage urgency algorithm may indicate a need for moreimmediate medical attention. Expert input provided for example throughexpert database may provide input for values of different factorsassigned to different suspected disease state 140 and/or symptomcomplaints. Expert input provided for example through expert databasemay provide start and end ranges for final triage urgency algorithmscores that may be categorized as belonging to a particular triageurgency category label 152. For instance and without limitation, aparticular range of scores between a start score and an end score may beindicative of a triage urgency category label 152 such as check-upappointment label while another particular range of scores between astart score and an end score may be indicative of a triage urgencycategory label 152 such as immediate attention label. “Body systemfactor” as used in this disclosure, is a factor that may indicate aparticular body system that is involved with a particular suspecteddisease state 140 and/or symptom complaint. Expert input may provideguidance as to which suspected disease state 140 and/or symptomcomplaints affecting particular body systems may warrant particularlevels of medical attention. For instance and without limitation, aparticular suspected disease state 140 such as irritable bowel syndromethat affects the gastrointestinal tract may contain a lower body systemfactor that does not need immediate medical attention, while a suspecteddisease state 140 such as a suspected heart attack affecting thecardiovascular system may contain a higher body system factor that doesneed immediate medical attention. In yet another non-limiting example, asuspected disease state 140 such as a cut on one's toe that affects theintegumentary system may contain a lower body system factor that can betreated at home, while a suspected disease state 140 such as aconcussion that affects the neurological system may contain a higherbody system factor that does need immediate medical attention. “Lifeendangerment factor” as used in this disclosure, is a factor that mayindicate a particular life threatening condition. Expert input mayprovide guidance as to which suspected disease state 140 and/or symptomcomplaints may be life threatening and may require more immediatemedical attention. For instance and without limitation, a particularsuspected disease state 140 such as Raynaud's syndrome may contain alower score indicating a non-urgent need for medical attention while aparticular suspected disease state 140 such as a hypertensive crisis maycontain a higher score indicating an urgent need for medical attention.In yet another non-limiting example, a particular suspected diseasestate 140 such as toenail fungus may contain a very low score indicatingan ability to self-treat at home, while a particular suspected diseasestate 140 such as rectal bleeding may contain a higher score indicatinga more urgent need for medical attention. “Alarm condition factor” asused in this disclosure, is a factor that may indicate how necessaryimmediate medical attention for a particular suspected disease state 140and/or symptom complaint may be needed. Expert input may provideguidance as to how urgent treatment for a particular suspected diseasestate 140 and/or symptom complaint may be needed. For instance andwithout limitation, a particular suspected disease state 140 such aschest pain may contain an alarm condition factor score indicating a moreurgent need for treatment while a particular suspected disease state 140such as a backache may contain a lower alarm condition factor treatmentindicating a less urgent need for treatment. In yet another non-limitingexample, a particular suspected disease state 140 such as loss ofconsciousness may contain a higher alarm condition factor scoreindicating a more urgent need for treatment while a particular suspecteddisease state 140 such as a skin rash may contain a lower alarmcondition factor score indicating a less urgent need for treatment.

With continued reference to FIG. 1, triage module 148 is configured toselect triage training data 156 as a function of the triage urgencycategory label 152 for each of the plurality of suspected disease state140 wherein the triage training data 156 correlates suspected diseasestate 140 to relative disease criticality scores. “Disease criticalityscore” as used in this disclosure, indicates how critical medicalattention and/or treatment may be needed for a particular disease.Triage training set may include a plurality of entries, each entrycorrelating at least a suspected disease state 140 to a relative diseasecriticality score. For instance and without limitation, triage trainingset may include a data entry that includes a suspected disease state 140such as measles having a high disease criticality index score indicatingthe need for immediate treatment. In yet another non-limiting example,triage training set may include a data entry that includes a suspecteddisease state 140 such as tooth ache having a low disease criticalityindex score indicating less of a need for immediate medical treatment.Disease criticality score may be further subdivided to include anintervention score, a constitutional expert score, and an alternativetreatment score. “Intervention score” as used in this disclosure,indicates how soon medical intervention may be needed as a function of asuspected disease state 140. Medical intervention includes medicalprocedure and/or course of action that may help in treating disease,medical conditions, and/or injury. Medical intervention may includemedical procedures that include outpatient procedures such as an x-ray,magnetic resonance image (MM), biopsy, screening test such as acolonoscopy or endoscopy, dental restoration, arthroscopy, burndebridement, platelet-rich plasma (PRP) injection, and the like. Medicalintervention may include medical procedures that include inpatientprocedures such as angiocardiography, cesarean section, diagnosticultrasound, cardiac catheterization, knee replacement, insertion ofcoronary artery stent, hip replacement and the like. For example, asuspected disease state 140 such as coronary artery disease may have ahigher intervention score indicating that medical intervention necessaryto reverse and/or treat coronary artery disease is needed sooner ascompared to a suspected disease state 140 such as an ingrown toenailwhich may have a lower intervention score indicating that medicalintervention is not needed as quickly. “Constitutional expert score” asused in this disclosure, indicates how soon an appointment with amedical professional should occur as a function of a suspected diseasestate 140. For example, a suspected disease state 140 such as Lupus maywarrant a higher constitutional expert score indicating an appointmentwith a medical professional in the very near immediate future isnecessary as compared to a suspected disease state 140 such as fatiguewhich may warrant a lower constitutional expert score indicating anappointment with a medical professional does not have to occurimmediately but may be suitable at a follow up appointment later on.“Alternative treatment score” as used in this disclosure, indicates howlikely a particular suspected disease state 140 can be managed withalternative treatments. Alternative treatments may include over thecounter medications such as nutraceuticals, homeopathic remedies,vitamins, minerals, supplements, natural remedies, herbals, and thelike. For instance and without limitation, a suspected disease state 140such as adrenal fatigue may contain a high alternative treatment scoreindicating a high likelihood of being managed with alternativetreatments while a suspected disease state 140 such as acute myocardialinfarction may contain a low alternative treatment score indicating alow likelihood of being managed with alternative treatments.

With continued reference to FIG. 1, triage module 148 is configured toselect triage training data 156. Triage module 148 may select triagetraining data 156 by matching a suspected disease state 140 to triagetraining data 156 containing the suspected disease state 140 containedwithin a triage urgency category label 152 database. Triage urgencycategory label 152 database may be implemented in any way suitable forimplementation of expert database as described above. Triage urgencycategory label 152 database may include a plurality of data entriesand/or records corresponding to particular triage training sets. Triagetraining sets may be organized according to triage urgency categorylabel 152 ad described in more detail below. Data entries in triageurgency category label 152 database may include additional elements ofinformation which may be reflected in data entry cells and/or in linkedtables such as tables related by one or more indices in a relationaldatabase. In an embodiment, triage module 148 may select triage trainingdata 156 by first matching triage urgency category label 152 to the sametriage urgency category label 152 contained within triage urgencycategory label 152 database and then to a triage training set containinga suspected disease state 140 contained within the match triage urgencycategory label 152. Selecting triage training data 156 as a function ofthe triage urgency category label 152 includes selecting a first triagetraining set from a triage urgency category label 152 database as afunction of the triage urgency category label 152, probing the firsttriage training set to locate a suspected disease state 140 and failingto locate the suspected disease state 140 within the first triagetraining set, discarding the first training set, selecting a secondtriage training set from the triage urgency category label 152 databaseas a function of the triage urgency category label 152, probing thesecond triage training set to locate a suspected disease state 140 andlocating the suspected disease state 140 within the second triagetraining set, and selecting the second triage training set. Selectingtriage training data may include choosing a supervised machine-learningdisease criticality model that was already created using a particulartriage training data set that is stored on at least a computing device104 and precomputed which can be utilized to generate outputs when givenany particular inputs. In an embodiment, at least a computing device 104may include a database containing precomputed disease criticality modelsthat may be selected. Persons skilled in the art, upon reviewing theentirety of this disclosure, will be aware of various ways in which dataentries in triage urgency category label 152 database may be organized.

With continued reference to FIG. 1, triage module 148 is configured togenerate using a supervised machine-learning processes a diseasecriticality model that receives each of the plurality of suspecteddisease state 140 and outputs a disease criticality score 164 for eachof the plurality of suspected disease state 140 utilizing the selectedtraining data. Supervised machine-learning algorithms, as definedherein, include algorithms that receive a training set relating a numberof inputs to a number of outputs, and seek to find one or moremathematical relations relating inputs to outputs, where each of the oneor more mathematical relations is optimal according to some criterionspecified to the algorithm using some scoring function. For instance, asupervised learning algorithm may include suspected disease state 140produced via lazy-learning processes as described above, diseasecriticality scores 164 as outputs, and a scoring function representing adesired form of relationship to be detected between inputs and outputs;scoring function may, for instance, seek to maximize the probabilitythat a given input and/or combination of elements inputs is associatedwith a given output to minimize the probability that a given input isnot associated with a given output. Scoring function may be expressed asa risk function representing an “expected loss” of an algorithm relatinginputs to outputs, where loss is computed as an error functionrepresenting a degree to which a prediction generated by the relation isincorrect when compared to a given input-output pair provided intraining data. Persons skilled in the art, upon reviewing the entiretyof this disclosure, will be aware of various possible variations ofsupervised machine-learning algorithms that may be used to determinerelation between inputs and outputs.

With continued reference to FIG. 1, triage module 148 is configured togenerate using a supervised machine-learning processes a diseasecriticality model that outputs a disease criticality score 164 for eachof the plurality of suspected disease state 140 utilizing the selectedtriage training data 156. Supervised machine-learning processes mayinclude classification algorithms, defined as processes whereby acomputing device 104 derives, from training data, a model for sortinginputs into categories or bins of data. Classification may be performedusing, without limitation, linear classifiers such as without limitationlogistic regression and/or naive Bayes classifiers, nearest neighborclassifiers, support vector machines, decision trees, boosted trees,random forest classifiers, and/or neural network-based classifiers.

Still referring to FIG. 1, machine-learning processes as described inthis disclosure may be used to generate machine-learning models. Amachine-learning model, as used herein, is a mathematical representationof a relationship between inputs and outputs, as generated using anymachine-learning process including without limitation any process asdescribed above, and stored in memory; an input is submitted to amachine-learning model once created, which generates an output based onthe relationship that was derived. For instance, and without limitation,a linear regression model, generated using a linear regressionalgorithm, may compute a linear combination of input data usingcoefficients derived during machine-learning processes to calculate anoutput datum. As a further non-limiting example, a machine-learningmodel may be generated by creating an artificial neural network, such asa convolutional neural network comprising an input layer of nodes, oneor more intermediate layers, and an output layer of nodes. Connectionsbetween nodes may be created via the process of “training” the network,in which elements from a training dataset are applied to the inputnodes, a suitable training algorithm (such as Levenberg-Marquardt,conjugate gradient, simulated annealing, or other algorithms) is thenused to adjust the connections and weights between nodes in adjacentlayers of the neural network to produce the desired values at the outputnodes. This process is sometimes referred to as deep learning, forinstance for multi-layered networks.

With continued reference to FIG. 1, triage module 148 is configured toevaluate the ranked disease criticality score for each of the pluralityof suspected disease state 140 as a function of ranking the diseasecriticality score 164 for each of the plurality of suspected diseasestate 140. Ranking may include classifying suspected disease state 140as a function of disease criticality score 164. Ranking may includeclassifying suspected disease state 140 such as in descending order ofdisease criticality score 164 whereby a suspected disease state 140 withthe highest disease criticality score 164 may be ranked first and asuspected disease state 140 with the lowest disease criticality score164 may be ranked last. In an embodiment, ranking may include rankingsuspected disease state 140 into sub-classifiers whereby suspecteddisease state 140 that affect a particular body system such as thenervous system may be ranked into a hierarchy of suspected disease state140 with the highest disease criticality score 164 ranked first thataffects the nervous system and a suspected disease state 140 with thelowest disease criticality score 164 that affects the nervous system maybe ranked last.

With continued reference to FIG. 1, evaluating the ranked diseasecriticality score for each of the plurality of suspected disease state140 includes receiving at least a user input datum wherein the at leasta user input datum further comprises a previous user diagnosis,selecting a suspected disease state 140 as a function of the previoususer diagnosis and the ranked disease criticality score and displayingthe selected suspected disease state 140 at a graphical user interface116 operating on at least a computing device 104. Previous userdiagnosis may include a description of a previous medical conditionand/or disease state that a user may have received from a medicalprofessional. Previous user diagnosis may be utilized to select and/oreliminate particular suspected disease state 140. For instance andwithout limitation, a previous user diagnosis such as Celiac Disease maybe utilized to eliminate a suspected disease state 140 from a pluralityof suspected disease such as gluten intolerance because the user isalready on a gluten free diet having received a previous diagnosis ofCeliac Disease. In yet another non-limiting example, a previous userdiagnosis such as Celiac Disease may be utilized to select a suspecteddisease state 140 such as lactose intolerance because of a known linkbetween Celiac Disease and lactose intolerance.

With continued reference to FIG. 1, triage module 148 is configured todisplay the ranked disease criticality score for each of the pluralityof suspected disease state 140 at a graphical user interface 116operating on at least a computing device 104. Displaying the rankeddisease criticality score may include displaying any sub-groups that maybe ranked as described in more detail above.

Referring now to FIG. 2, an exemplary embodiment 200 of KNN module 108is illustrated. KNN module 108 may be implemented as a hardware orsoftware module. KNN module 108 is configured to receive a plurality ofsymptom complaint datum 112 generated by a user at a graphical userinterface 116 operating on at least a computing device 104, receivesuspected disease state training data 128 correlating at least anelement of symptom complaint data to suspected disease state vectorsfrom an expert knowledge database 132 located on the at least acomputing device 104, calculate an optimal vector output 136 for each ofthe plurality of symptom complaint datum 112 utilizing a k-nearestneighbor algorithm 204 and the suspected disease state training data128, and generate an optimal vector output 136 containing a suspecteddisease state 140 for each of the plurality of symptom complaints.

With continued reference to FIG. 2, KNN module 108 receives a pluralityof symptom complaint datum 112 generated by a user at a graphical userinterface 116 and/or user interface 120 as described above in moredetail in reference to FIG. 1. Plurality of symptom complaint datum 112may contain a description of body symptoms and/or medical conditionsthat a user may be experiencing. For instance and without limitation,plurality of symptom complaint datum 112 may include a first symptomcomplaint datum 112 that includes a symptom such as “head pain,” asecond symptom complaint datum 112 that includes a symptom such as“watery eyes,” and a third symptom complaint datum 112 that includes asymptom such as “wet productive cough.” In an embodiment, user may enterplurality of symptom complaint datum 112 through user interface 120featuring a spoken option wherein the user interface 120 converts oralspoken symptom complaint datum 112 to textual symptom complaint datum112.

With continued reference to FIG. 2, KNN module 108 receives suspecteddisease state training data 128 correlating at least an element ofsymptom complaint data to suspected disease state 140 from an expertknowledge database 132 located on at least a computing device 104. In anembodiment, expert knowledge database 132 may contain suspected diseasestate training data 128 organized by symptom complaints, whereby asymptom complaint datum is utilized to select a suspected disease state140 training set located within expert knowledge database 132 asdescribed in more detail below. Training data sets contained withinexpert knowledge database 132 may be received from expert inputs such asby top medical experts, journal articles, and scientific studies asdescribed in more detail below.

With continued reference to FIG. 2, KNN module 108 may include anoptimal vector output 136 calculator 208 that calculates an optimalvector output 136 for each of the plurality of symptom complaint datum112 utilizing a k-nearest neighbor algorithm 204 and the suspecteddisease state training data 128. K-nearest neighbor algorithm 204includes a lazy-learning process as described above in more detail inreference to FIG. 1. K-nearest neighbor algorithm 204 may generate asuspected disease state 140 output by classifying suspected diseasestate training data 128 to find the most similar data entries containedwithin the suspected disease state training data 128. KNN module 108 maymodify suspected disease state training data 128 by representingsuspected disease state training data 128 as vectors. Vectors mayinclude mathematical representations of suspected disease state trainingdata 128. Vectors may include n-tuple of values which may represent ameasurement or other quantitative value associated with a given categoryof data, or attribute. Vectors may be represented in n-dimensional spaceusing an axis per category of value represented in n-tuple of values,such that a vector has a geometric direction characterizing the relativequantities of attributes in the n-tuple as compared to each other. In anembodiment, KNN module 108 may calculate an initial heuristic rankingassociation between inputs and elements of suspected disease statetraining data 128. Initial heuristic may include selecting some numberof highest-ranking associations and/or training data elements. KNNmodule 108 may perform one or more processes to modify and/or formatsuspected disease state training data 128. Suspected disease statetraining data 128 may contain “N” unique features, whereby a datasetcontained within suspected disease state training data 128 andrepresented as a vector may contain a vector of length “N” whereby entry“I” of the vector represents that data point's value for feature “I.”Each vector may be mathematically represented as a point in“R{circumflex over ( )}N.” For instance and without limitation, KNNmodule 108 may modify entries contained within suspected disease statetraining data 128 to contain consistent forms of a variance. Afterappropriate selection of suspected disease state training data 128 fromexpert knowledge database 132, KNN module 108 performs K-nearestneighbor algorithm 204 by classifying datasets contained withinsuspected disease state 140 training set. Suspected disease statetraining data 128 may be represented as an “M×N” matrix where “M” is thenumber of data points contained within the suspected disease statetraining data 128 and “N” is the number of features contained within thesuspected disease state training data 128. Classifying datasetscontained within suspected disease state 140 training set may includecomputing a distance value between an item to be classified such as asymptom complaint and each dataset contained within suspected diseasestate 140 training set which may be represented as a vector. A value of“k” may be pre-determined or selected that will be used forclassifications. In an embodiment, value of “k” may be selected as anodd number to avoid a tied outcome. In an embodiment, value of “k” maybe decided by KNN module 108 arbitrarily or value may be cross validatedto find an optimal value of “k.”. KNN module 108 may then select adistance metric that will be used in K-nearest neighbor algorithm 204.In an embodiment, KNN module 108 may utilize Euclidean distance whichmay be measure distance by subtracting the distance between a trainingdata point and the datapoint to be classified such as symptom complaintdatum 112. In an embodiment, Euclidean distance may be calculated by aformula represented as: E(x,y)=√{square root over (Σ_(i=0)^(n)(xi−yi)²)}. In an embodiment, KNN module 108 may utilize metricdistance of cosine similarity which may calculate distance as thedifference in direction between two vectors which may be represented as:similarity=cos 0=A×B÷∥A∥∥B∥. After selection of “k” value, and selectionof distance measurement by KNN module 108, KNN module 108 may partitionin “R{circumflex over ( )}N” into sections. Sections may be calculatedusing the distance metric and the available data points contained withinsuspected disease state 140 training set. KNN module 108 may calculate aplurality of optimal vector output 136; in such an instance, where aplurality of matching entries are returned, optimal vector output 136may be obtained by aggregating matching entries including any suitablemethod for aggregation, including component-wise addition followed bynormalization component-wise calculation of arithmetic means, or thelike. Optimal vector output 136 may be generated by receiving a userentry containing a datum of user genetic history which may be utilizedto update a suspected disease state 140 contained within an optimalvector output 136. For instance and without limitation, a datum of usergenetic history that contains one copy of the apolipoprotein E gene maybe utilized to select between two optimal vector output 136 whereby afirst optimal vector output 136 contains a suspected disease state 140such as coronary artery disease and a second optimal vector output 136contains a suspected disease state 140 such as anxiety disorder. In suchan instance, datum of user genetic history containing apolipoprotein Egene may be utilized to select optimal vector output 136 containingsuspected disease state 140 of coronary artery disease.

Referring now to FIG. 3, an exemplary embodiment 300 of expert knowledgedatabase 132 is illustrated. Expert knowledge database 132 may, as anon-limiting example, organize data stored in the expert knowledgedatabase 132 according to one or more database tables. One or moredatabase tables may be linked to one another by, for instance, commoncolumn values. For instance, a common column between two tables ofexpert knowledge database 132 may include an identifier of an expertsubmission, such as a form entry, textual submission, expert paper, orthe like, for instance as defined below; as a result, a query may beable to retrieve all rows from any table pertaining to a givensubmission or set thereof. Other columns may include any other categoryusable for organization or subdivision of expert data, including typesof expert data, names and/or identifiers of experts submitting the data,times of submission, or the like; persons skilled in the art, uponreviewing the entirety of this disclosure, will be aware of various waysin which expert data may be included in one or more tables.

With continued reference to FIG. 3, expert knowledge database 132includes a forms processing module 304 that may sort data entered in asubmission via graphical user interface 116 and/or user interface 120by, for instance, sorting data from entries in the first graphical userinterface 116 to related categories of data; for instance, data enteredin an entry relating in the graphical user interface 116 to a trainingdata set may be sorted into variables and/or data structures for storageof training data sets, while data entered in an entry relating to acategory of suspected disease state 140 data and/or an element thereofmay be sorted into variables and/or data structures for the storage of,respectively, categories of suspected disease state 140 data. Where datais chosen by an expert from pre-selected entries such as drop-downlists, data may be stored directly; where data is entered in textualform, language processing module 124 may be used to map data to anappropriate existing label, for instance using a vector similarity testor other synonym-sensitive language processing test to map physiologicaldata to an existing label. Alternatively or additionally, when alanguage processing algorithm, such as vector similarity comparison,indicates that an entry is not a synonym of an existing label, languageprocessing module 124 may indicate that entry should be treated asrelating to a new label; this may be determined by, e.g., comparison toa threshold number of cosine similarity and/or other geometric measuresof vector similarity of the entered text to a nearest existent label,and determination that a degree of similarity falls below the thresholdnumber and/or a degree of dissimilarity falls above the thresholdnumber. Data from expert textual submissions 308, such as accomplishedby filling out a paper or PDF form and/or submitting narrativeinformation, may likewise be processed using language processing module124. Data may be extracted from expert papers 312, which may includewithout limitation publications in medical and/or scientific journals,by language processing module 124 via any suitable process as describedherein. Persons skilled in the art, upon reviewing the entirety of thisdisclosure, will be aware of various additional methods whereby novelterms may be separated from already-classified terms and/or synonymstherefore, as consistent with this disclosure.

With continued reference to FIG. 3, one or more database tables inexpert knowledge database 132 may include expert training data table316; expert training data table 316 may contain training data sets suchas suspected disease state training data. In an embodiment, suspecteddisease state training data contained within expert training data table316 may be organized by symptom complaint, whereby a user entry throughgraphical user interface 116 and/or user interface 120 containing asymptom complaint may be matched to a symptom complaint contained withinexpert training data table 316. Suspected disease state training datacontained within expert training data table 316 may be received based onexpert inputs such as from functional medicine doctors, top journals,papers and the like. One or more database tables in expert knowledgedatabase 132 may include expert suspected disease state table 320;expert suspected disease state 140 table may contain data entriescontaining symptom complaints experienced by users with particulardisease states. For instance and without limitation, expert suspecteddisease state table 320 may include a suspected disease state 140 suchas common cold and symptom complaints experienced by users with thecommon cold including fever, stuffy nose, watery eyes, sneezing,headache, chills, and body aches. One or more database tables in expertknowledge database 132 may include expert triage category label table324; expert triage category label table 324 may include informationdescribing particular symptom complaints and/or suspected disease state140 and associated triage labels. For instance and without limitation,expert triage category label table 324 may include a particular symptomcomplaint such as chest pain with an associated triage label such asattention in near future. One or more database tables in expertknowledge database 132 may include expert genetic history table 328;expert genetic history table 328 may include entries describingparticular genetic history and predisposition for particular diseasestates. For instance and without limitation, expert genetic historytable 328 may include an entry describing breast cancer 1 gene (BRCA 1)and susceptibility to develop breast cancer. One or more database tablesin expert knowledge database 132 may include expert body system table332; expert body system table 332 may include one or more entriesdescribing impact of one or more symptom complaints on one or more bodysystems. For instance and without limitation, expert body system table332 may include symptom complaint such as headache impacting the nervoussystem. One or more database tables in expert knowledge database 132 mayinclude expert life endangerment table 336; expert life endangermenttable 336 may include one or more entries describing one or more symptomcomplaints and effect on life endangerment. For instance and withoutlimitation, expert life endangerment table may include a symptomcomplaint such as coughing up blood as endangering life.

Referring now to FIG. 4, an exemplary embodiment of graphicalrepresentation 400 of k-nearest neighbor algorithm 184 is illustrated.Embodiment 404 represents datapoint to be classified. Datapoint to beclassified may include symptom complaint. Embodiment 408 represents datasets from selected suspected disease state training data. Embodiment 408may be represented as “m” number of datasets contained within suspecteddisease state training data. Embodiment 412 indicates a first “k” valueselected and the corresponding number of datasets contained utilizingfirst “k” value. Embodiment 416 indicate a second “k” value selected andthe corresponding number of datasets contained utilizing second “k”value. Embodiment 420 represents distance between datapoint to beclassified embodiment 404 and a particular dataset from suspecteddisease state training data embodiment 408. Embodiment 424 representsdistance between datapoint to be classified embodiment 404 and aparticular dataset from suspected disease state training data embodiment408. Distance may be measured utilizing any of the methodologies asdescribed above in reference to FIG. 2, including for example Euclideandistance and/or cosine similarity.

Referring now to FIG. 5, an exemplary embodiment 500 of user database144 is illustrated. One or more database tables in user database 144 mayinclude user demographic table 504; user demographic table may includestored demographic information pertaining to a user. For instance andwithout limitation, user demographic table 504 may include user contactinformation, home address, allergies, payment information, maritalstatus, household income, occupation, age, gender, and the like. One ormore database tables in user database 144 may include user genetichistory table 508; user genetic history table may include stored genetichistory data pertaining to a user. For instance and without limitation,user genetic history table 508 may include stored user genetic testresults such as a result from a positive test result for the HLA-classII complex gene DQ2 and DQ8 commonly associated with Celiac Disease. Oneor more database tables in user database 144 may include user physicalsample table 512; user physical sample table 512 may include medicalhistory and medical files of various physically extracted samples usermay have tested for particular genetic history data. For instance andwithout limitation, user physical sample table 512 may include asalivary sample analyzed for particular genetic history data and a hairsample analyzed for particular genetic history data. One or moredatabase tables contained within user database 144 may include userprevious diagnosis table 516; user previous diagnosis table 516 mayinclude previous medical diagnoses that a user may have received from amedical professional. For instance and without limitation, user previousdiagnosis table 516 may include a user's previous diagnoses such asalopecia, hypertension, and prostatitis.

Referring now to FIG. 6, an exemplary embodiment 600 of triage module148 is illustrated. Triage module 148 may be implemented as a hardwareor software module. Triage module 148 is configured to receive anoptimal vector output 136 containing a suspected disease state 140 foreach of the plurality of symptom complaint datum 112, generate a triageurgency category label 152 for each of the plurality of suspecteddisease state 140 wherein the triage urgency category label 152 furthercomprises matching the optimal vector output 136 containing a suspecteddisease state 140 for each of the plurality of symptom complaint datum112 to a triage urgency category label 152; select a triage trainingdata 156 as a function of the triage urgency category label 152 for eachof the plurality of suspected disease state 140 wherein the triagetraining data 156 correlates suspected disease state 140 to relativedisease criticality scores; generate using a supervised machine-learningprocesses a disease criticality model that outputs a disease criticalityscore 164 for each of the plurality of suspected disease state 140utilizing the selected triage training data 156; evaluate the rankeddisease criticality score for each of the plurality of suspected diseasestate 140 as a function of ranking the disease criticality score 164 foreach of the plurality of suspected disease state 140; and display theranked disease criticality score for each of the plurality of suspecteddisease state 140 at the graphical user interface 116 operating on theat least a computing device 104.

With continued reference to FIG. 6, triage module 148 receives optimalvector output 136 containing a suspected disease state 140 for each ofthe plurality of symptom complaint datum 112 from KNN module 108. Triagemodule 148 may contain a triage urgency category label module 604 thatgenerates a triage urgency category label 152 for each of the pluralityof suspected disease state 140. Triage urgency category label module 604may generate triage urgency category label 152 by matching optimalvector output 136 containing a suspected disease state 140 to a triageurgency category label 152. Triage urgency category label 152 mayinclude any of the triage urgency category label 152 described above inreference to FIG. 1. Triage urgency category label 152 may includeimmediate attention label when medical attention is needed in less than1 year, near future label when medical attention is needed in the nearfuture in less than 3 hours, next day label when medical attention isneeded in the next day, next week label when medical attention is neededin the next week, check-up label when medical attention is needed at thenext scheduled check-up, and self-care label when medical attention isnot needed and may be provided at home. Triage urgency category labelmodule 604 may match suspected disease state 140 to triage urgencycategory label 152 by calculating a triage urgency algorithm. Triageurgency algorithm includes multiplying a body system factor by a lifeendangerment factor and an alarm condition factor. Factors utilized incalculating triage urgency algorithm are described above in more detailin reference to FIG. 1. In an embodiment, a higher total score fortriage urgency algorithm may indicate a higher level of urgency and maycause a suspected disease state 140 to be classified into a more urgenturgency category label such as immediate attention or attention in nearfuture. In an embodiment, a lower total score for triage urgencyalgorithm may indicate a lower level of urgency and may cause asuspected disease state 140 to be classified into a less urgent urgencycategory label such as attention in next check-up or self-care. In anembodiment, expert input may guide start and end points for triageurgency algorithm scores to be classified with particular triage urgencylabels. Expert input may be received utilizing any of the methods asdescribed above in reference to FIG. 3.

With continued reference to FIG. 6, triage module 148 selects trainingdata as a function of the triage urgency category label 152 for each ofthe plurality of suspected disease state 140 wherein the triage trainingdata 156 correlates suspected disease state 140 to relative diseasecriticality scores 164. Triage module 148 may select triage trainingdata 156 from triage urgency database 160. In an embodiment, triagemodule 148 may select triage training data 156 from triage urgencydatabase 160 by matching a suspected disease state 140 to training datacontaining the suspected disease state 140 contained within triageurgency database 160 as described in more detail below. For instance andwithout limitation, triage module 148 may receive an optimal vectoroutput 136 containing a suspected disease state 140 of hypertension. Insuch an instance, triage module 148 may match suspected disease state140 of lupus to a training set that contains a data entry of lupuscorrelated relative disease criticality score for lupus. Triage module148 may select triage training data 156 by selecting a first triagetraining set from triage database as a function of triage urgencycategory label 152. For instance and without limitation, triage module148 may select triage training data 156 by matching a suspected diseasestate 140 such as gastritis containing a triage urgency category label152 of attention in next day to a triage training set located withintriage database containing a triage urgency category label 152 ofattention in next day. Triage module 148 may then probe the first triagetraining set to locate a suspected disease state 140. In theaforementioned gastritis example, triage module 148 may probe firsttriage training set to see if it contains a data entry containinggastritis correlated to a relative disease criticality score. Failing tolocate a suspected disease state 140 within a first training set willcause triage module 148 to discard the first training set. Triage module148 may then select a second triage training set from triage urgencydatabase 160 as a function of a triage urgency category label 152 andprobe the second triage training set to locate a suspected disease state140. Locating a suspected disease state 140 within a second triagetraining set will allow triage module 148 to select second triagetraining set to generate an unsupervised machine-learning model. In anembodiment, triage module 148 may continue to select triage trainingsets from triage urgency database 160 until a suspected disease state140 is located within a triage training set.

With continued reference to FIG. 6, triage module 148 may includesupervised machine-learning module 608. Supervised machine-learningmodule may generate using a supervised machine-learning model a diseasecriticality model that outputs a disease criticality score 164 for eachof the plurality of suspected disease state 140 utilizing the selectedtriage training data 156. Supervised machine-learning model outputs adisease criticality score 164 for each of the plurality of suspecteddisease state 140 utilizing the selected triage training data 156.Supervised machine-learning model may include any of the supervisedmachine-learning models as described above in reference to FIG. 1.Supervised machine-learning model may utilize suspected disease state140 as an input and utilize the selected triage training data 156 tooutput a disease criticality score 164 for the suspected disease state140. Triage module 148 may evaluate the disease criticality score foreach of the plurality of suspected disease state 140 as a function ofranking the disease criticality scores 164 for each of the plurality ofsuspected disease state 140. Disease criticality score 164 indicates howcritical medical attention and/or treatment may be needed for aparticular disease. In an embodiment, triage module 148 may rank diseasecriticality scores 164 in descending order of how critical medicalattention may be needed based on disease criticality scores 164. Triagemodule 148 may evaluate ranked disease criticality score for each of theplurality of suspected disease state 140. Triage module 148 may receiveat least a user input datum containing a previous user diagnosis. In anembodiment, triage module 148 may retrieve previous user diagnosisinformation from user database 144 as described in more detail above inreference to FIG. 5. Triage module 148 may select a suspected diseasestate 140 as a function of previous user diagnosis and ranked diseasecriticality score. For instance and without limitation, a previous userdiagnosis of ulcerative colitis may be utilized to select a suspecteddisease state 140 of dehydration as compared to a suspected diseasestate 140 such as the flu due to known associations with ulcerativecolitis and complications that include dehydration. Triage module 148may display ranked disease criticality score for each of the pluralityof suspected disease state 140 at graphical user interface 116 operatingon at least a computing device 104.

Referring now to FIG. 7, an exemplary embodiment 700 of triage urgencycategory label module 604 is illustrated. Triage urgency category labelmodule 604 may receive suspected disease state 140 and classifysuspected disease state 140 to a triage urgency category label 152. Thismay be performed utilizing any of the methodologies as described abovein FIG. 1 and FIG. 6. Triage urgency category label 152 may includeimmediate attention label 704 when medical attention is needed in lessthan one hour. Triage urgency category label 152 may include attentionin near future label 708 when medical attention is needed within thenext three hours. Triage urgency category label 152 may includeattention in next day label 712 when medical attention is needed withinthe next twenty four hours. Triage urgency category label 152 mayinclude attention in next week label 716 when medical attention isneeded within the next week. Triage urgency category label 152 mayinclude attention in next check-up label 720 when medical attention isneeded at the user's next scheduled checkup. Triage urgency categorylabel 152 may include self-care label 724 when medical attention is notneeded, and the user can provide treatment himself or herself at home.Selected triage urgency category label 152 may then be utilized bytriage module 148 to select triage training data 156 from triage urgencydataset. In an embodiment, triage urgency category label 152 may bematched to triage training sets contained within triage urgency database160 that are organized according to triage urgency labels.

Referring now to FIG. 8, an exemplary embodiment 800 of triage urgencydatabase 160 is illustrated. One or more tables contained within triageurgency database 160 includes heart attack immediate attention table804; heart attack immediate attention table 804 may include all triagetraining sets containing heart attack disease state and containingimmediate attention triage urgency label. One or more tables containedwithin triage urgency database 160 may include influenza attention nextweek table 808; influenza attention next week table 808 may include alltriage training sets containing influenza disease state and containingattention next week urgency label. One or more tables contained withintriage urgency database 160 may include headache self-are table 812;headache self-care table 812 may include all triage training setscontaining headache disease state and containing self-care triageurgency category label 152. One or more tables contained within triageurgency database 160 may include gout table 816; gout table 816 mayinclude all triage training sets containing gout disease state. One ormore tables contained within triage urgency database 160 may includeattention in next day table 820; attention in next day table 820 mayinclude all triage training sets containing triage urgency categorylabel 152 of attention in next day. One or more tables contained withintriage urgency database 160 may include self-care table 824; self-caretable 824 may include all triage training sets containing triage urgencycategory label 152 of self-care.

Referring now to FIG. 9, an exemplary embodiment of a method 900 ofprioritizing user symptom complaint inputs. At step 905 a KNN module 108operating on at least a computing device 104 receives a plurality ofsymptom complaint datum 112 by a user at a graphical user interface 116operating on at least a computing device 104. Symptom complaint datum112 may include any of the constitution complaint datums as describedabove in reference to FIGS. 1-9. For instance and without limitation,symptom complaint datum 112 may include user generated complaints suchas “headache,” “back pain,” “foot numbness” and “sore ankles.” In anembodiment, KNN module 108 receives a plurality of symptom complaintdatum 112 generated by a user at a user interface 120 operating on atleast a computing device 104. User interface 120 may include any of theuser interface 120 as described above in reference to FIG. 1. Userinterface 120 may be configured to convert oral spoken symptom complaintdatum 112 to textual symptom complaint datum 112. This may be doneutilizing any of the language processing methods described above inreference to FIG. 1.

With continued reference to FIG. 9, at step 910 a KNN module 108operating on at least a computing device 104 receives suspected diseasestate training data correlating at least an element of symptom complaintdata to suspected disease state 140 from an expert knowledge database132 located on at least a computing device 104. KNN module 108 receivessuspected disease state training data utilizing any of the methodologiesas described above in reference to FIGS. 1-9. Expert knowledge database132 may include any of the expert knowledge database 132 as describedabove in reference to FIG. 1 and FIG. 3.

With continued reference to FIG. 9, at step 915 a KNN module 108operating on at least a computing device 104 calculates an optimalvector output 136 for each of the plurality of symptom complaint datum112 utilizing a k-nearest neighbor algorithm and the suspected diseasestate training data. Calculating optimal vector output 136 may beperformed utilizing any of the methodologies as described above inreference to FIGS. 1-9. Calculating optimal vector output 136 includesidentifying the presence of a symptom complaint datum 112 and confirminga suspected disease state 140. For instance and without limitation,identifying the presence of a symptom complaint datum 112 such as kneepain may be utilized to confirm a suspected disease state 140 such asosteoarthritis. In yet another non-limiting example, identifying thepresence of a symptom complaint datum 112 such as muscle twitching maybe utilizing to confirm a suspected disease state 140 such as multiplesclerosis. Calculating an optimal vector output 136 includes identifyingthe presence of a symptom complaint datum 112 and eliminating asuspected disease state 140. For instance and without limitation, asymptom complaint datum 112 such as eye pain may be utilized toeliminate a suspected disease state 140 such as a myocardial infarction.In yet another non-limiting example, a symptom complaint datum 112 suchas an earache may be utilized to eliminate a suspected disease state 140such as foot fungus.

With continued reference to FIG. 9, generating optimal vector output 136includes displaying optimal vector output 136 containing a suspecteddisease state 140 to a user, receiving a user entry containing asuspected disease state 140 to the user, receiving a user entrycontaining a datum of user genetic history, and updating the optimalvector output 136 containing a new suspected disease state 140 as afunction of the user entry. User entry containing a datum of usergenetic history may be retrieved from user database 144. For instanceand without limitation, a user genetic history such as a mutation of theSLC23A1 gene that controls Vitamin C absorption may be utilized toselect an updated optimal vector output 136 that includes a suspecteddisease state 140 of rickets. In yet another non-limiting example, auser genetic history such as a mutation of the GC gene responsible fortransporting Vitamin D and showing reduced transportation may beutilized to select an updated optimal vector output 136 that includes asuspected disease state 140 of osteoarthritis.

With continued reference to FIG. 9, calculating optimal vector output136 includes utilizing k-nearest neighbor algorithm and the suspecteddisease state training data. This may be performed utilizing any of themethodologies as described above in reference to FIGS. 1-9. K-nearestneighbor algorithm may include any of the k-nearest neighbor algorithmsas described above in reference to FIGS. 1-9.

With continued reference to FIG. 9, at step 920 KNN module 108 operatingon at least a computing device 104 generates an optimal vector output136 containing a suspected disease state 140 for each of the pluralityof symptom complaint datum 112. Suspected disease state 140 may includeany of the suspected disease state 140 as described above in referenceto FIGS. 1-9. Triage module 148 operating on at least a computing device104 receives an optimal vector output 136 for each of the plurality ofsymptom complaint datum 112.

With continued reference to FIG. 9, at step 925 triage module 148operating on at least a computing device 104 generates a triage urgencycategory label 152 for each of the plurality of suspected disease state140 wherein the triage urgency category label 152 further comprisesmatching optimal vector output 136 containing a suspected disease state140 for each of the plurality of symptom compliant datums to a triageurgency category label 152. This may be performed utilizing any of themethodologies as described above in reference to FIGS. 1-9. Triageurgency category label 152 may be generated as a function of calculatinga triage urgency algorithm wherein the triage urgency algorithm furthercomprises multiplying a body system factor by a life endangerment factorand an alarm condition factor. This may be performed utilizing any ofthe methodologies as described above in reference to FIGS. 1-9. Factorsutilized to calculate triage urgency algorithm may include any of thefactors as described above in reference to FIGS. 1-9.

With continued reference to FIG. 9, at step 930 triage module 148operating on at least a computing device 104 selects triage trainingdata 156 as a function of triage urgency category label 152 for each ofthe plurality of suspected disease state 140 wherein the triage trainingdata 156 correlates suspected disease state 140 to relative diseasecriticality scores. Triage training data 156 may include any of thetriage training data 156 as described above in reference to FIGS. 1-9.Selecting triage training data 156 includes matching a suspected diseasestate 140 to training data containing the suspected disease state 140contained within a triage urgency category label 152 database. This maybe implemented utilizing any of the methodologies as described above inreference to FIGS. 6-8. Selecting triage training data 156 as a functionof the triage urgency category label 152 includes selecting a firsttriage training set from a triage urgency category label 152 database asa function of the triage urgency category label 152. Triage module 148probes the first triage training set to locate a suspected disease state140 and failing to locate the suspected disease state 140 within thefirst triage training set discards the first triage training set. Triagemodule 148 selects a second triage training set from the triage urgencycategory label 152 database as a function of the triage urgency categorylabel 152. Triage module 148 probes the second triage training set tolocate a suspected disease state 140 and locating the suspected diseasestate 140 within the second triage training set. Triage module 148selects the second triage training set. In an embodiment, triage module148 may continue to select training sets until a training set contains asuspected disease state 140. For instance and without limitation, triagemodule 148 may select and discard seven triage training sets beforeselecting an eight training set containing the suspected disease state140. Triage training sets may be classified and organized by suspecteddisease type and/or triage urgency category label 152 as described abovein more detail in FIG. 8.

With continued reference to FIG. 9, at step 935 triage module 148operating on at least a computing device 104 generates using asupervised machine-learning model a disease criticality model thatoutputs a disease criticality score for each of the plurality ofsuspected disease state 140 utilizing the selected triage training data156. Generating supervised machine-learning model may be done utilizingany of the methodologies as described above in reference to FIGS. 1-9.Disease criticality score may include any of the disease criticalityscores as described above in reference to FIGS. 1-9. Disease criticalityscore may include an intervention score, a constitutional expert score,and an alternative treatment score, which may be calculated utilizingany of the methodologies as described above in reference to FIG. 1.

With continued reference to FIG. 9, at step 940 triage module 148operating on at least a computing device 104 evaluates the rankeddisease criticality score for each of the plurality of suspected diseasestate 140 as a function of ranking the disease criticality score foreach of the plurality of suspected disease state 140, receiving at leasta user input datum wherein the at least a user input datum furthercomprises a previous user diagnosis, selecting a suspected disease state140 as a function of the previous user diagnosis and the ranked diseasecriticality score; and displaying the selected suspected disease state140 at the graphical user interface 116 operating on the at least acomputing device 104. For instance and without limitation, triage module148 may receive a previous user diagnosis such as rheumatoid arthritiswhich may be utilized to select a suspected disease state 140 such ashypothyroidism due to a link of both being autoimmune diseases ascompared to selecting a suspected disease state 140 such as fatigue.Previous user diagnosis may be useful to select a suspected diseasestate 140 when a plurality of suspected disease state 140 may containsimilar disease criticality scores.

With continued reference to FIG. 9, at step 945 triage module 148operating on at least a computing device 104 displays ranked diseasecriticality score for each of the plurality of suspected disease state140 at the graphical user interface 116 operating on at least acomputing device 104.

It is to be noted that any one or more of the aspects and embodimentsdescribed herein may be conveniently implemented using one or moremachines (e.g., one or more computing device 104 that are utilized as auser computing device 104 for an electronic document, one or more serverdevices, such as a document server, etc.) programmed according to theteachings of the present specification, as will be apparent to those ofordinary skill in the computer art. Appropriate software coding canreadily be prepared by skilled programmers based on the teachings of thepresent disclosure, as will be apparent to those of ordinary skill inthe software art. Aspects and implementations discussed above employingsoftware and/or software modules may also include appropriate hardwarefor assisting in the implementation of the machine executableinstructions of the software and/or software module.

Such software may be a computer program product that employs amachine-readable storage medium. A machine-readable storage medium maybe any medium that is capable of storing and/or encoding a sequence ofinstructions for execution by a machine (e.g., a computing device 104)and that causes the machine to perform any one of the methodologiesand/or embodiments described herein. Examples of a machine-readablestorage medium include, but are not limited to, a magnetic disk, anoptical disc (e.g., CD, CD-R, DVD, DVD-R, etc.), a magneto-optical disk,a read-only memory “ROM” device, a random access memory “RAM” device, amagnetic card, an optical card, a solid-state memory device, an EPROM,an EEPROM, and any combinations thereof. A machine-readable medium, asused herein, is intended to include a single medium as well as acollection of physically separate media, such as, for example, acollection of compact discs or one or more hard disk drives incombination with a computer memory. As used herein, a machine-readablestorage medium does not include transitory forms of signal transmission.

Such software may also include information (e.g., data) carried as adata signal on a data carrier, such as a carrier wave. For example,machine-executable information may be included as a data-carrying signalembodied in a data carrier in which the signal encodes a sequence ofinstruction, or portion thereof, for execution by a machine (e.g., acomputing device 104) and any related information (e.g., data structuresand data) that causes the machine to perform any one of themethodologies and/or embodiments described herein.

Examples of a computing device 104 include, but are not limited to, anelectronic book reading device, a computer workstation, a terminalcomputer, a server computer, a handheld device (e.g., a tablet computer,a smartphone, etc.), a web appliance, a network router, a networkswitch, a network bridge, any machine capable of executing a sequence ofinstructions that specify an action to be taken by that machine, and anycombinations thereof. In one example, a computing device 104 may includeand/or be included in a kiosk.

FIG. 10 shows a diagrammatic representation of one embodiment of acomputing device 104 in the exemplary form of a computer system 1000within which a set of instructions for causing a control system toperform any one or more of the aspects and/or methodologies of thepresent disclosure may be executed. It is also contemplated thatmultiple computing device 104 may be utilized to implement a speciallyconfigured set of instructions for causing one or more of the devices toperform any one or more of the aspects and/or methodologies of thepresent disclosure. Computer system 1000 includes a processor 1004 and amemory 1008 that communicate with each other, and with other components,via a bus 1012. Bus 1012 may include any of several types of busstructures including, but not limited to, a memory bus, a memorycontroller, a peripheral bus, a local bus, and any combinations thereof,using any of a variety of bus architectures.

Memory 1008 may include various components (e.g., machine-readablemedia) including, but not limited to, a random access memory component,a read only component, and any combinations thereof. In one example, abasic input/output system 1016 (BIOS), including basic routines thathelp to transfer information between elements within computer system1000, such as during start-up, may be stored in memory 1008. Memory 1008may also include (e.g., stored on one or more machine-readable media)instructions (e.g., software) 1020 embodying any one or more of theaspects and/or methodologies of the present disclosure. In anotherexample, memory 1008 may further include any number of program modulesincluding, but not limited to, an operating system, one or moreapplication programs, other program modules, program data, and anycombinations thereof.

Computer system 1000 may also include a storage device 1024. Examples ofa storage device (e.g., storage device 1024) include, but are notlimited to, a hard disk drive, a magnetic disk drive, an optical discdrive in combination with an optical medium, a solid-state memorydevice, and any combinations thereof. Storage device 1024 may beconnected to bus 1012 by an appropriate interface (not shown). Exampleinterfaces include, but are not limited to, SCSI, advanced technologyattachment (ATA), serial ATA, universal serial bus (USB), IEEE 1394(FIREWIRE), and any combinations thereof. In one example, storage device1024 (or one or more components thereof) may be removably interfacedwith computer system 1000 (e.g., via an external port connector (notshown)). Particularly, storage device 1024 and an associatedmachine-readable medium 1028 may provide nonvolatile and/or volatilestorage of machine-readable instructions, data structures, programmodules, and/or other data for computer system 1000. In one example,software 1020 may reside, completely or partially, withinmachine-readable medium 1028. In another example, software 1020 mayreside, completely or partially, within processor 1004.

Computer system 1000 may also include an input device 1032. In oneexample, a user of computer system 1000 may enter commands and/or otherinformation into computer system 1000 via input device 1032. Examples ofan input device 1032 include, but are not limited to, an alpha-numericinput device (e.g., a keyboard), a pointing device, a joystick, agamepad, an audio input device (e.g., a microphone, a voice responsesystem, etc.), a cursor control device (e.g., a mouse), a touchpad, anoptical scanner, a video capture device (e.g., a still camera, a videocamera), a touchscreen, and any combinations thereof. Input device 1032may be interfaced to bus 1012 via any of a variety of interfaces (notshown) including, but not limited to, a serial interface, a parallelinterface, a game port, a USB interface, a FIREWIRE interface, a directinterface to bus 1012, and any combinations thereof. Input device 1032may include a touch screen interface that may be a part of or separatefrom display 1036, discussed further below. Input device 1032 may beutilized as a user selection device for selecting one or more graphicalrepresentations in a graphical interface as described above.

A user may also input commands and/or other information to computersystem 1000 via storage device 1024 (e.g., a removable disk drive, aflash drive, etc.) and/or network interface device 1040. A networkinterface device, such as network interface device 1040, may be utilizedfor connecting computer system 1000 to one or more of a variety ofnetworks, such as network 1044, and one or more remote devices 1048connected thereto. Examples of a network interface device include, butare not limited to, a network interface card (e.g., a mobile networkinterface card, a LAN card), a modem, and any combination thereof.Examples of a network include, but are not limited to, a wide areanetwork (e.g., the Internet, an enterprise network), a local areanetwork (e.g., a network associated with an office, a building, a campusor other relatively small geographic space), a telephone network, a datanetwork associated with a telephone/voice provider (e.g., a mobilecommunications provider data and/or voice network), a direct connectionbetween two computing device 104, and any combinations thereof. Anetwork, such as network 1044, may employ a wired and/or a wireless modeof communication. In general, any network topology may be used.Information (e.g., data, software 1020, etc.) may be communicated toand/or from computer system 1000 via network interface device 1040.

Computer system 1000 may further include a video display adapter 1052for communicating a displayable image to a display device, such asdisplay device 1036. Examples of a display device include, but are notlimited to, a liquid crystal display (LCD), a cathode ray tube (CRT), aplasma display, a light emitting diode (LED) display, and anycombinations thereof. Display adapter 1052 and display device 1036 maybe utilized in combination with processor 1004 to provide graphicalrepresentations of aspects of the present disclosure. In addition to adisplay device, computer system 1000 may include one or more otherperipheral output devices including, but not limited to, an audiospeaker, a printer, and any combinations thereof. Such peripheral outputdevices may be connected to bus 1012 via a peripheral interface 1056.Examples of a peripheral interface include, but are not limited to, aserial port, a USB connection, a FIREWIRE connection, a parallelconnection, and any combinations thereof.

The foregoing has been a detailed description of illustrativeembodiments of the invention. Various modifications and additions can bemade without departing from the spirit and scope of this invention.Features of each of the various embodiments described above may becombined with features of other described embodiments as appropriate inorder to provide a multiplicity of feature combinations in associatednew embodiments. Furthermore, while the foregoing describes a number ofseparate embodiments, what has been described herein is merelyillustrative of the application of the principles of the presentinvention. Additionally, although particular methods herein may beillustrated and/or described as being performed in a specific order, theordering is highly variable within ordinary skill to achieve methods,systems, and software according to the present disclosure. Accordingly,this description is meant to be taken only by way of example, and not tootherwise limit the scope of this invention.

Exemplary embodiments have been disclosed above and illustrated in theaccompanying drawings. It will be understood by those skilled in the artthat various changes, omissions and additions may be made to that whichis specifically disclosed herein without departing from the spirit andscope of the present invention.

What is claimed is:
 1. A system for prioritizing user symptom complaintinputs the system comprising: at least a computing device, wherein theat least a computing device further comprises one or more networkinterfaces, a non-volatile memory, and one or more processors; aK-nearest neighbors (KNN) module operating on the at least a computingdevice, the KNN module designed and configured to: receive a pluralityof symptom complaint datums generated by a user at a graphical userinterface operating on the at least a computing device; receive from anexpert knowledge database located on the at least a computing device,suspected disease state training data correlating at least an element ofsymptom complaint data to suspected disease states; calculate an optimalvector output for each of the plurality of symptom complaint datumsutilizing a k-nearest neighbor algorithm and the suspected disease statetraining data; and generate an optimal vector output containing asuspected disease state for each of the plurality of symptom complaintdatums; and a triage module operating on the at least a computing devicethe triage module designed and configured to: receive the optimal vectoroutput containing a suspected disease state for each of the plurality ofsymptom complaint datums; generate a triage urgency category label foreach of the plurality of suspected disease states wherein the triageurgency category label further comprises matching the optimal vectoroutput containing a suspected disease state for each of the plurality ofsymptom complaint datums to a triage urgency category label; selecttriage training data as a function of the triage urgency category labelfor each of the plurality of suspected disease states wherein the triagetraining data correlates suspected disease states to relative diseasecriticality scores; generate using a supervised machine-learning model adisease criticality model that inputs each of the plurality of suspecteddisease states and outputs a disease criticality score as a function ofthe selected triage training data, wherein each of the plurality ofsuspected disease states is generated by a lazy-learning process and arisk function representing an expected loss; evaluate the diseasecriticality score for each of the plurality of suspected disease statesas a function of ranking the disease criticality score for each of theplurality of suspected disease states; and display the ranked diseasecriticality score for each of the plurality of suspected disease statesat the graphical user interface.
 2. The system of claim 1, wherein theKNN module is further configured to receive a plurality of symptomcomplaint datums generated by a user at a user interface operating onthe at least a computing device wherein the user interface is designedand configured to generate speech-to-text algorithms to transform spokensymptom complaint datums into text symptom complaint datums.
 3. Thesystem of claim 1, wherein calculating an optimal vector output furthercomprises: identifying the presence of a symptom complaint datum; andconfirming a suspected disease state.
 4. The system of claim 1, whereincalculating an optimal vector output further comprises: identifying thepresence of a symptom complaint datum; and eliminating a suspecteddisease state.
 5. The system of claim 1, wherein generating an optimalvector output further comprises: displaying the optimal vector outputcontaining a suspected disease state to the user; receiving a user entrycontaining a datum of user genetic history; and updating the optimalvector output containing a new suspected disease state as a function ofthe user entry.
 6. The system of claim 1, wherein the triage urgencycategory label is generated as a function of calculating a triageurgency algorithm wherein the triage urgency algorithm further comprisesmultiplying a body system factor by a life endangerment factor, and byan alarm condition factor.
 7. The system of claim 1, wherein selectingtriage training data as a function of the triage urgency category labelfurther comprises matching a suspected disease state to triage trainingdata containing the suspected disease state contained within a triageurgency database.
 8. The system of claim 1, wherein selecting triagetraining data as a function of the triage urgency category label furthercomprises: selecting a first triage training set from a triage urgencydatabase as a function of the triage urgency category label; probing thefirst triage training set to locate a suspected disease state andfailing to locate the suspected disease state within the first triagetraining set; discarding the first triage training set; selecting asecond triage training set from the triage urgency database as afunction of the triage urgency category label; probing the second triagetraining set to locate a suspected disease state and locating thesuspected disease state within the second triage training set; andselecting the second triage training set.
 9. The system of claim 1,wherein evaluating the ranked disease criticality score for each of theplurality of suspected disease states further comprises: receiving atleast a user input datum wherein the at least a user input datum furthercomprises a previous user diagnosis; selecting a suspected disease stateas a function of the previous user diagnosis and the ranked diseasecriticality score; and displaying the selected suspected disease stateat the graphical user interface operating on the at least a computingdevice.
 10. The system of claim 1, wherein the disease criticality scorefurther comprises an intervention score, a constitutional expert score,and an alternative treatment score.
 11. A method of prioritizing usersymptom complaint inputs the system comprising: receiving by at least acomputing device a plurality of symptom complaint datums generated by auser at a graphical user interface operating on the at least a computingdevice; receiving by the at least a computing device a suspected diseasestate training data correlating at least an element of symptom complaintdata to suspected disease states from an expert knowledge databaselocated on the at least a computing device; calculating by the at leasta computing device an optimal vector output for each of the plurality ofsymptom complaint datums utilizing a k-nearest neighbor algorithm andthe suspected disease state training data; generating by the at least acomputing device an optimal vector output containing a suspected diseasestate for each of the plurality of symptom complaint datums; generatingby the at least a computing device a triage urgency category label foreach of the plurality of suspected disease states wherein the triageurgency category label further comprises matching the optimal vectoroutput containing a suspected disease state for each of the plurality ofsymptom complaint datums to a triage urgency category label; selectingby the at least a computing device a triage training data as a functionof the triage urgency category label for each of the plurality ofsuspected disease states wherein the triage training data correlatessuspected disease states to relative disease criticality scores;generating by the at least a computing device using a supervisedmachine-learning model a disease criticality model that inputs each ofthe plurality of suspected disease states and outputs a diseasecriticality score for each of the plurality of suspected disease statesas a function of the selected triage training data, wherein each of theplurality of suspected disease states are generated by a lazy-learningprocess and a scoring risk function representing an expected loss;evaluating by the at least a computing device the disease criticalityscore for each of the plurality of suspected disease states as afunction of ranking the disease criticality score for each of theplurality of suspected disease states; and displaying by the at least acomputing device the ranked disease criticality score for each of theplurality of suspected disease states at the graphical user interfaceoperating on the at least a computing device.
 12. The method of claim11, wherein receiving a plurality of symptom complaint datums furthercomprises receiving a plurality of symptom complaint datums generated bya user at a user interface operating on the at least a computing devicewherein the user interface generates speech-to-text algorithms totransform spoken symptom complaint datums into text symptom complaintdatums.
 13. The method of claim 11, wherein calculating an optimalvector output further comprises: identifying the presence of a symptomcomplaint datum; and confirming a suspected disease state.
 14. Themethod of claim 11, wherein calculating an optimal vector output furthercomprises: identifying the presence of a symptom complaint datum; andeliminating a suspected disease state.
 15. The method of claim 11,wherein generating an optimal vector output further comprises:displaying the optimal vector output containing a suspected diseasestate to the user; receiving a user entry containing a datum of usergenetic history; and updating the optimal vector output containing a newsuspected disease state as a function of the user entry.
 16. The methodof claim 11, wherein the triage urgency category label is generated as afunction of calculating a triage urgency algorithm wherein the triageurgency algorithm further comprises multiplying a body system factor bya life endangerment factor, and by an alarm condition factor.
 17. Themethod of claim 11, wherein selecting triage training data as a functionof the triage urgency category label further comprises matching asuspected disease state to triage training data containing the suspecteddisease state contained within a triage urgency database.
 18. The methodof claim 11, wherein selecting triage training data as a function of thetriage urgency category label further comprises: selecting a firsttriage training set from a triage urgency database as a function of thetriage urgency category label; probing the first triage training set tolocate a suspected disease state and failing to locate the suspecteddisease state within the first triage training set; discarding the firsttriage training set; selecting a second triage training set from thetriage urgency database as a function of the triage urgency categorylabel; probing the second triage training set to locate a suspecteddisease state and locating the suspected disease state within the secondtriage training set; and selecting the second triage training set. 19.The method of claim 11, wherein evaluating the ranked diseasecriticality score for each of the plurality of suspected disease statesfurther comprises: receiving at least a user input datum wherein the atleast a user input datum further comprises a previous user diagnosis;selecting a suspected disease state as a function of the previous userdiagnosis and the ranked disease criticality score; and displaying theselected suspected disease state at the graphical user interfaceoperating on the at least a computing device.
 20. The method of claim11, wherein the disease criticality score further comprises anintervention score, a constitutional expert score, and an alternativetreatment score.